Atiprosin
Clinical data
Other namesAY-28,228
Routes of
administration		Oral
ATC code
  • none
Identifiers
  • (4aR,12bS)-1-ethyl-12-methyl-4-(propan-2-yl)-1,2,3,4,4a,5,6,12b-octahydropyrazino[2',3':3,4]pyrido[1,2-a]indole
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC20H29N3
Molar mass311.473 g·mol−1
3D model (JSmol)
  • n23c1ccccc1c(c2[C@H]4N(CCN([C@@H]4CC3)C(C)C)CC)C
  • InChI=1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1 checkY
  • Key:WXNVFYIBELASJW-QUCCMNQESA-N checkY
 ☒NcheckY (what is this?)  (verify)

Atiprosin (developmental code name AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]

See also

References

  1. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
  2. ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry. 30 (2): 388–94. doi:10.1021/jm00385a022. PMID 3806618.
  3. ^ a b Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology. 10 (3): 249–58. doi:10.1097/00005344-198709000-00001. PMID 2444771. S2CID 9361176.
  4. ^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology. 10 (3): 341–9. doi:10.1097/00005344-198709000-00014. PMID 2444784. S2CID 19086175.

External links


Sympatholytic (and closely related) antihypertensives (C02)
Adrenergic receptor modulators
Histamine receptor modulators
Tricyclics
Categories