Atypical fibroxanthoma
Specialty	Oncology, rheumatology

Atypical fibroxanthoma of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically.^[1]: 613

Diagnosis

Differential diagnoses

• Squamous cell carcinoma
• Malignant fibrous histiocytoma

Treatment

Surgical excision with clear margins.^{[citation needed]}

Epidemiology

It occurs most commonly on the skin of sun-exposed, elderly patients. The majority of tumours are on the scalp, face, ears and upper limbs, but less commonly the tumour occurs on the limbs and trunk when there is a lack of association with sun exposure in younger individuals. The condition has also been noted in organ transplant recipients who may be in a state of immunosuppression. It has been reported that there is a predominance in men (70% men versus 30% women).^[2]