Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Identifiers
EC no.2.4.1.102
CAS no.95978-15-7
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Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, beta6-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase, core 2 acetylglucosaminyltransferase, core 6-beta-GlcNAc-transferase A, UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R

References

  1. ^ Brockhausen I, Rachaman ES, Matta KL, Schachter H (August 1983). "The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis". Carbohydrate Research. 120: 3–16. doi:10.1016/0008-6215(83)88002-1. PMID 6226356.
  2. ^ Williams D, Longmore G, Matta KL, Schachter H (December 1980). "Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase". The Journal of Biological Chemistry. 255 (23): 11253–61. PMID 6449508.
  3. ^ Williams D, Schachter H (December 1980). "Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates". The Journal of Biological Chemistry. 255 (23): 11247–52. PMID 6449507.

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Transferases: glycosyltransferases (EC 2.4)
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