B3GAT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D0J
Identifiers
Aliases	B3GAT2, GLCATS, beta-1,3-glucuronyltransferase 2
External IDs	OMIM: 607497 MGI: 2389490 HomoloGene: 50574 GeneCards: B3GAT2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q13 Start 70,856,679 bp[1] End 70,957,060 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A5 Start 23,800,834 bp[2] End 23,888,239 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in entorhinal cortex ganglionic eminence pons Brodmann area 46 postcentral gyrus hippocampus proper endothelial cell corpus callosum secondary oocyte superior frontal gyrus Top expressed in proximal tubule urethra kidney superior frontal gyrus neural tube tongue cerebellar cortex secondary oocyte spermatocyte esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity metal ion binding galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process glycosaminoglycan metabolic process protein glycosylation chondroitin sulfate proteoglycan biosynthetic process chondroitin sulfate metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 135152 280645 Ensembl ENSG00000112309 ENSMUSG00000026156 UniProt Q9NPZ5 P59270 RefSeq (mRNA) NM_080742 NM_172124 RefSeq (protein) NP_542780 NP_742122 Location (UCSC) Chr 6: 70.86 – 70.96 Mb Chr 1: 23.8 – 23.89 Mb PubMed search [3] [4]
Wikidata
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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.^[5][6]

The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.^[6]

Use of HNK-1 Antibody for Neural Crest Research

Antibodies raised against the HNK-1 epitope have played a large role in studies of the neural crest, especially in the avian embryo.^[7] The first antibody raised against this epitope was NC-1,^[8] which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.