BACH2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBACH2, BTBD25, BTB domain and CNC homolog 2, IMD60
External IDsOMIM: 605394 MGI: 894679 HomoloGene: 7240 GeneCards: BACH2
Orthologs
SpeciesHumanMouse
Entrez

60468

12014

Ensembl

ENSG00000112182

ENSMUSG00000040270

UniProt

Q9BYV9

P97303

RefSeq (mRNA)

NM_001170794
NM_021813

NM_001109661
NM_007521

RefSeq (protein)

NP_001164265
NP_068585

NP_001103131

Location (UCSC)Chr 6: 89.93 – 90.3 MbChr 4: 32.24 – 32.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene.[5][6][7] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [8] and a bZip_Maf domain at the C-terminus.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112182 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040270 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (August 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene. 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928.
  6. ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (November 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood. 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606.
  7. ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2".
  8. ^ Rosbrook GO, Stead MA, Carr SB, Wright SC (January 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond" (PDF). Acta Crystallographica Section D. 68 (Pt 1): 26–34. doi:10.1107/S0907444911048335. PMID 22194330.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Transcription factors and intracellular receptors
Categories