BMX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EKX, 2YS2, 3SXR, 3SXS
Identifiers
Aliases	BMX, ETK, PSCTK2, PSCTK3, BMX non-receptor tyrosine kinase
External IDs	OMIM: 300101 MGI: 1101778 HomoloGene: 20411 GeneCards: BMX
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 15,464,246 bp[1] End 15,556,529 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 162,975,838 bp[2] End 163,041,189 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis bone marrow right coronary artery subcutaneous adipose tissue right lung Achilles tendon urethra bone marrow cells blood ascending aorta Top expressed in atrioventricular valve atrium endocardial cushion right lung lobe bone marrow blood secondary oocyte left lung left lung lobe carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity signal transducer activity metal ion binding kinase activity protein binding protein tyrosine kinase activity signaling receptor binding ATP binding non-membrane spanning protein tyrosine kinase activity Cellular component cytoplasm cytosol extrinsic component of cytoplasmic side of plasma membrane ruffle membrane nucleoplasm plasma membrane Biological process intracellular signal transduction phosphorylation NK T cell differentiation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation cell adhesion regulation of cell population proliferation peptidyl-tyrosine autophosphorylation protein autophosphorylation mesoderm development innate immune response signal transduction apoptotic process phosphatidylinositol biosynthetic process adaptive immune response B cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 660 12169 Ensembl ENSG00000102010 ENSMUSG00000031377 UniProt P51813 P97504 RefSeq (mRNA) NM_001721 NM_203281 NM_001320866 NM_009759 RefSeq (protein) NP_001307795 NP_001712 NP_975010 NP_033889 Location (UCSC) Chr X: 15.46 – 15.56 Mb Chr X: 162.98 – 163.04 Mb PubMed search [3] [4]
Wikidata
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Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.^[5][6]

Function

Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.^[6]

Interactions

BMX has been shown to interact with:

• PAK1,^[7]
• PTK2,^[8]
• PTPN21^[9] and
• RUFY1.^[10]