POU class 4 homeobox 1
Identifiers
SymbolPOU4F1
Alt. symbolsBRN3A
NCBI gene5457
HGNC9218
OMIM601632
RefSeqNM_006237
UniProtQ01851
Other data
LocusChr. 13 q31.1
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POU class 4 homeobox 2
Identifiers
SymbolPOU4F2
Alt. symbolsBRN3B
NCBI gene5458
HGNC9219
OMIM113725
RefSeqNM_004575
UniProtQ12837
Other data
LocusChr. 4 q31.22
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POU class 4 homeobox 3
Identifiers
SymbolPOU4F3
Alt. symbolsBRN3C, DFNA15
NCBI gene5459
HGNC9220
OMIM602460
RefSeqNM_002700
UniProtQ15319
Other data
LocusChr. 5 q32
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StructuresSwiss-model
DomainsInterPro

BRN-3 is a group of related transcription factors in the POU family.[1] They are also known as class 4 POU domain homeobox proteins.

There are three BRN-3 proteins encoded by the following genes:

Nomenclature

The BRN or Brn prefix is an abbreviation for "brain"; the longer name is "Brain-specific homeobox". The name of the group may also be abbreviated as POU4, Pou4, POU IV, or POU-IV.

References

  1. ^ Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, Eddy RL, Shows TB, Nathans J (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. doi:10.1523/JNEUROSCI.15-07-04762.1995. PMC 6577904. PMID 7623109.

External links


Transcription factors and intracellular receptors
Categories