Barrios is a Spanish surname. Notable people with the surname include:

• Agustín Barrios (1885–1944), Paraguayan guitarist and composer
• Ángel Barrios (1882–1964), Spanish guitarist and composer
• Arturo Barrios (born 1962), Mexican athlete
• Bayang Barrios (born 1968), Filipino musician
• Edison Barrios (born 1988), Venezuelan professional baseball player
• Eduardo Barrios (1884–1963), Chilean writer
• Gerardo Barrios (1813–1865), President of El Salvador (1859-1863)
• Gonzalo Barrios (politician) (1902–1993), Venezuelan politician
• Gonzalo Barrios (esports player) (born 1995), Chilean-American Super Smash Bros. player
• Gracia Barrios (1927–2020), Chilean painter
• Ignacio Barrios (1930–2013), Mexican painter
• Jarrett Barrios (born 1969), American politician, President of the Gay & Lesbian Alliance Against Defamation (GLAAD)
• Jorge Barrios (footballer) (born 1961), Uruguayan footballer
• Jorge Rodrigo Barrios (born 1976), Argentine boxer
• Juan Luis Barrios (born 1983), Mexican athlete
• Justo Rufino Barrios (1835–1885), President of Guatemala (1873-1885)
• Lucas Barrios (born 1984), Argentine-born Paraguayan footballer
• Lucho Barrios (1935–2010), Peruvian musician
• Luis Barrios (born 1990), Peruvian basketball player
• Lya Barrioz, Nicaraguan singer and actress whose real name is Ligia Barrios
• Manuel Barrios (born 1974), Panamanian baseball player
• Sonny Barrios, Filipino basketball player
• Teófilo Barrios (born 1964), Paraguayan football (soccer) defender
• Yarelis Barrios (born 1983), Cuban discus thrower