Bay K8644^[1]

Names
Preferred IUPAC name Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Identifiers
CAS Number	71145-03-4 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:34555 N
ChEMBL	ChEMBL1082832 N
ChemSpider	2213 N
ECHA InfoCard	100.163.930
EC Number	636-102-2
IUPHAR/BPS	2511
PubChem CID	2303
CompTox Dashboard (EPA)	DTXSID00913080
InChI InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 N Key: ZFLWDHHVRRZMEI-UHFFFAOYSA-N N InChI=1/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 Key: ZFLWDHHVRRZMEI-UHFFFAOYAV
SMILES CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
Properties
Chemical formula	C16H15F3N2O4
Molar mass	356.301 g·mol−1
Solubility in water	Insoluble
Solubility in other solvents	DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL
Hazards
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319
Precautionary statements	P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Bay K8644 is a chemical compound that functions as an L-type calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.^[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.

Mechanism of action

Bay K8644 targets L-type voltage-gated calcium channels. It is the first positive inotropic agent shown to act specifically and directly on calcium channels.^[3]