Benzoylecgonine is the compound tested for in most substantive cocaine drug urinalyses.
Presence in drinking water
Benzoylecgonine is sometimes found in drinking water supplies. In 2005, scientists found surprisingly large quantities of benzoylecgonine in Italy's Po River and used its concentration to estimate the number of cocaine users in the region.[3] In 2006, a similar study was performed in the Swiss ski town of Saint-Moritz using wastewater to estimate the daily cocaine consumption of the population.[4] A study done in the United Kingdom found traces of benzoylecgonine in the country's drinking water supply, along with carbamazepine (an anticonvulsant) and ibuprofen (a common non-steroidal anti-inflammatory drug), although the study noted that the amount of each compound present was several orders of magnitude lower than the therapeutic dose and therefore did not pose a risk to the population.[5]
Preliminary studies on ecological systems show that benzoylecgonine has potential toxicity issues.[6] Research is being conducted on degradation options such as advanced oxidation and photocatalysis[7] for this metabolite in an effort to reduce concentrations in waste and surface waters. At environmentally relevant concentrations, benzoylecgonine has been shown to have a negative ecological impact.[6]
^ abBinelli, A.; Marisa, I; Fedorova, M; Hoffmann, R; Riva, C (2013). "First evidence of protein profile alteration due to the main cocaine metabolite (benzoylecgonine) in a freshwater model". Aquatic Toxicology. 140–141: 268–278. doi:10.1016/j.aquatox.2013.06.013. PMID23838174.
^Postigo, C.; Sirtori, C.; Oller, I.; Malato, S.; Maldonado, M.I.; Lopez de Alda, M.; Barcelo, D. (2011). "Solar transformation and photocatalytic treatment of cocaine in water: kinetics, characterization of major intermediate products and toxicity evaluation". Applied Catalysis B: Environmental. 104 (1–2): 37–48. doi:10.1016/j.apcatb.2011.02.030.
