Big E may refer to:

• Capital letter "E"

People

• Big E (wrestler) (born 1986), American professional wrestler, born Ettore Ewen, formerly known as "Big E Langston"
• Elvin Hayes (born 1945; nicknamed "Big E"), American basketball player and radio analyst
• Eric Lindros (born 1973; nicknamed "Big E"), Canadian ice hockey player

Places

• Eyjafjallajökull, Iceland; the ice cap covering the stratovolcano known as "Big E"
• The Big E, West Springfield, Massachusetts, USA; a fairgounds that holds the annual The Big E agricultural fair
  • The Big E Coliseum, West Springfield, Massachusetts, USA; a 5,900-seat multi-purpose arena on the grounds of The Big E
• Eldora Speedway, nicknamed "The Big E", a dirt motorsports track near New Weston, Ohio, USA

Ships

• USS Enterprise (CV-6) (nicknamed "Big E"), the sixth aircraft carrier of the United States Navy
• USS Enterprise (CVN-65) (nicknamed "Big E"), the world's first nuclear-powered aircraft carrier

Other uses

• First letter at the top of an English-language eye chart
• The Big E, the only cross-state agricultural fair in the United States, held annually in West Springfield, Massachusetts
• Big E (supermarket). supermarket chain in Indianapolis, Indiana