Names | |
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IUPAC name
1,10-Dimethoxyaporphine-2,9-diol
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Systematic IUPAC name
(6aS)-1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol | |
Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.006.828 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C19H21NO4 | |
Molar mass | 327.380 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Boldine is an alkaloid of the aporphine class that can be found in the boldo tree. It is the most abundant aporphine alkaloid found in Boldo.[1] Boldine is also found in Lindera aggregata.[2]
Boldine has been investigated for its cyto-protective, anti-tumour promoting, anti-inflammatory, anti-diabetic and anti-atherogenic effect and is particularly believed to be a strong antioxidant.[3][4]
Boldine has shown nootropic activity in mice, specifically by significantly improving learning and memory. [5]
Boldine has shown antiepileptic activity in mice against seizures induced by Pentylenetetrazole (PTZ). [6]
Boldine protects against paracetamol induced liver inflammation and acute hepatic necrosis in mice. [7]
Boldine is a 5-HT3 receptor antagonist.[8] 5-HT3A antagonists have been shown to help prevent nausea and vomiting as well as the negative effects of serotonin in the G.I tract. [9][10]
Glaucine is structurally related to Boldine. Glaucine is a dimethyl ether analog of Boldine.
Topical use of DiAcetyl-Boldine in the form of a microemulsion has been studied for chemoprotection against Melanoma.[11]