Bruce H. Lipshutz (born 1951) is an American chemist. He is a professor at the University of California, Santa Barbara.^[1]

Biography

Lipshutz received his undergraduate degree in chemistry from Binghamton University in 1973. His graduate work was supervised by Harry H. Wasserman at Yale. After a PhD degree in 1977, he spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award.^[2] He is Co-founder of Zymes LLC.^[3]

Contributions

Reagents

• Aqueous Micellar Catalysis using TPGS-750-M^[4] and Nok.^[5]
• Sustainable Palladium catalysis.^[6][7]
• 2-(Trimethylsilyl)ethoxymethyl chloride: hydroxyl protecting group, selectively cleaved with fluoride ion under mild conditions.^[8]
• Di-(4-chlorobenzyl)azodicarboxylate (DCAD): recyclable and convenient alternative to diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD) in Mitsunobu reaction.^[9]
• Ligated copper hydride.^[10][11]
• Heterogeneous catalysts: nickel-on-charcoal, copper-on-charcoal, nickel-in-graphite, copper+nickel-on-charcoal.

Methodologies

• Higher-order organocuprates (Lipshutz cuprates).^[12]
• Chiral and achiral conjugate reductions.
• Catalyst development for ppm Pd-catalyzed C-C couplings in water at ambient^[13][14]
• Use of nonionic amphiphiles for transition metal-mediated cross coupling in organic synthesis.^[15]
• Low-cost synthesis of Coenzyme Q10.^[16][17]