BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof.

BxPC-3 cells were derived from a 61-year-old female in 1986, and were confirmed to be tumorigenic in athymic nude mice, with moderate differentiation.[1] The cells produce mucin, and exhibit an epithelial morphology.[2] BxPC-3 cells lack a KRAS mutation,[3] though it is commonly found in pancreatic cancers.[4] BcPC-3 cells, along with JoPaca-1 cells, have high expression of cancer stem cell markers.[5]

BxPC-3 has been used in tumorigenicity studies, pancreatic cancer therapy research, and other biomedical applications. The cells have been additionally studied for their phenotypic and genotypic properties as they can be applied to pancreatic cancer drug development; in particular, BxPC-3 cells have high expression of the angiogenic factors IL-8, VEGF, and PGE2, which can serve as potential drug targets.[6]

See also

References

  1. ^ Tan, Mong H.; et al. (1986). "Characterization of a New Primary Human Pancreatic Tumor Line". Cancer Investigation. 4 (1): 15–23. doi:10.3109/07357908609039823. PMID 3754176.
  2. ^ "ECACC General Cell Collection: BxPC-3". Public Health England. Retrieved 25 June 2018.
  3. ^ "Cellosaurus BxPC-3 (CVCL_0186)". Cellosaurus. Retrieved 25 June 2018.
  4. ^ Berrozpe, G; et al. (15 July 1994). "Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer". International Journal of Cancer. 58 (2): 185–191. doi:10.1002/ijc.2910580207. PMID 8026879. S2CID 40118099.
  5. ^ Fredebohm, Johannes; et al. (12 November 2012). "Establishment and Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System". PLOS ONE. 7 (11): e48503. Bibcode:2012PLoSO...748503F. doi:10.1371/journal.pone.0048503. PMC 3495919. PMID 23152778.
  6. ^ Deer, Emily; et al. (May 2010). "Phenotype and Genotype of Pancreatic Cancer Cell Lines". Pancreas. 39 (4): 425–435. doi:10.1097/MPA.0b013e3181c15963. PMC 2860631. PMID 20418756.

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