Chromosome 9 open reading frame 156 is a protein that in humans is encoded by the C9orf156 gene.[1] The gene is also known as NAP1 and HSPC219; the orthologue in mice is 5830415F09Rik.[1]
Characteristic | Phenotype |
---|---|
Homozygote viability | Normal |
Fertility | Normal |
Body weight | Normal |
Anxiety | Normal |
Neurological assessment | Normal |
Grip strength | Normal |
Hot plate | Normal |
Dysmorphology | Normal |
Indirect calorimetry | Normal |
Glucose tolerance test | Normal |
Auditory brainstem response | Normal |
DEXA | Normal |
Radiography | Normal |
Body temperature | Normal |
Eye morphology | Normal |
Clinical chemistry | Normal |
Haematology | Normal |
Peripheral blood lymphocytes | Normal |
Micronucleus test | Normal |
Heart weight | Normal |
Skin Histopathology | Normal |
Brain histopathology | Normal |
Salmonella infection | Normal[2] |
Citrobacter infection | Normal[3] |
All tests and analysis from[4][5] |
Model organisms have been used in the study of C9orf156 function. A conditional knockout mouse line, called 5830415F09Riktm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty four tests were carried out on mutant mice, but no significant abnormalities were observed.[4]