CA11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA11, CARPX1, carbonic anhydrase 11, CA-RP II, CA-RP, CARP-2, CA-XI
External IDsOMIM: 604644 MGI: 1336193 HomoloGene: 36061 GeneCards: CA11
Orthologs
SpeciesHumanMouse
Entrez

770

12348

Ensembl

ENSG00000063180

ENSMUSG00000003273

UniProt

O75493

O70354

RefSeq (mRNA)

NM_001217

NM_009800
NM_001368349

RefSeq (protein)

NP_001208

NP_033930
NP_001355278

Location (UCSC)Chr 19: 48.64 – 48.65 MbChr 7: 45.35 – 45.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene.[5][6]

Function

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[6]

Interactions

CA11 has been shown to interact with RIPK1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063180 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003273 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WW, Tashian RE (December 1998). "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3". Genomics. 54 (3): 484–93. doi:10.1006/geno.1998.5585. PMID 9878252.
  6. ^ a b "Entrez Gene: CA11 carbonic anhydrase XI".
  7. ^ Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El-Deiry WS, Schütze S, Srinivasula SM (May 2008). "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation". Curr. Biol. 18 (9): 641–9. Bibcode:2008CBio...18..641L. doi:10.1016/j.cub.2008.04.017. PMC 2587165. PMID 18450452.

External links

Further reading


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