chemokine (C-C motif) ligand 13
Identifiers
SymbolCCL13
Alt. symbolsSCYA13, MCP-4, NCC-1, SCYL1, CKb10
NCBI gene6357
HGNC10611
OMIM601391
RefSeqNM_005408
UniProtQ99616
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines.[1][2] CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5.[3] Activity of this chemokine has been implicated in allergic reactions such as asthma.[4] CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α.

References

  1. ^ Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626
  2. ^ Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.
  3. ^ Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
  4. ^ Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.



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