chemokine (C-C motif) ligand 14
Identifiers
SymbolCCL14
Alt. symbolsSCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF
NCBI gene6358
HGNC10612
OMIM601392
RefSeqNM_032962
UniProtQ16627
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.[1] CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.[2]

References

  1. ^ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.
  2. ^ Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.



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