CCL22
Identifiers
AliasesCCL22, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1, C-C motif chemokine ligand 22
External IDsOMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCards: CCL22
Orthologs
SpeciesHumanMouse
Entrez

6367

20299

Ensembl

ENSG00000102962

n/a

UniProt

O00626

O88430

RefSeq (mRNA)

NM_002990

NM_009137

RefSeq (protein)

NP_002981

NP_033163

Location (UCSC)Chr 16: 57.36 – 57.37 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.[4][5][6]

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4.[7] The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102962 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997). "Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells". J Exp Med. 185 (9): 1595–604. doi:10.1084/jem.185.9.1595. PMC 2196293. PMID 9151897.
  5. ^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. S2CID 46851784.
  6. ^ "Entrez Gene: CCL22 chemokine (C-C motif) ligand 22".
  7. ^ Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001). "Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo". Eur. J. Immunol. 31 (3): 812–22. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. hdl:11379/240109. PMID 11241286.
  8. ^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. S2CID 46851784.
  9. ^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

Further reading

External links

Cell signaling: cytokines
Chemokine receptor modulators
Categories