chemokine (C-C motif) ligand 23
Identifiers
SymbolCCL23
Alt. symbolsSCYA23, Ckb-8, MPIF-1, MIP-3, CKb8
NCBI gene6368
HGNC10622
OMIM602494
PDB1G91
RefSeqNM_005064
UniProtP55773
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.[1] It is also expressed in some cell lines of myeloid origin. CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells.[1] The gene for CCL23 is located on human chromosome 17 in a locus containing several other CC chemokines. CCL23 is a ligand for the chemokine receptor CCR1.[2]

References

  1. ^ a b Patel et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997.
  2. ^ Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.



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