CD109
Identifiers
Aliases	CD109, CPAMD7, p180, r150, CD109 molecule
External IDs	OMIM: 608859 MGI: 2445221 HomoloGene: 25183 GeneCards: CD109
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q13 Start 73,695,785 bp[1] End 73,828,316 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E1 Start 78,522,828 bp[2] End 78,623,535 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia synovial membrane vulva nipple gums Achilles tendon stromal cell of endometrium human penis synovial joint visceral pleura Top expressed in calvaria spermatid body of femur skin of back ankle cornea lip epidermis belly cord esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity transforming growth factor beta binding serine-type endopeptidase inhibitor activity Cellular component cell surface anchored component of membrane membrane extracellular region extracellular space plasma membrane platelet alpha granule membrane Biological process hair follicle development negative regulation of protein phosphorylation regulation of keratinocyte differentiation osteoclast fusion negative regulation of wound healing negative regulation of peptidase activity negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of keratinocyte proliferation negative regulation of endopeptidase activity platelet degranulation C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 135228 235505 Ensembl ENSG00000156535 ENSMUSG00000046186 UniProt Q6YHK3 Q8R422 RefSeq (mRNA) NM_001159587 NM_001159588 NM_133493 NM_153098 RefSeq (protein) NP_001153059 NP_001153060 NP_598000 NP_694738 Location (UCSC) Chr 6: 73.7 – 73.83 Mb Chr 9: 78.52 – 78.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD109 (Cluster of Differentiation 109) is a human gene.^[5]

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15),^[6] implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]^[5]