SPN
Identifiers
Aliases	SPN, CD43, GALGP, GPL115, LSN, sialophorin, LEU-22
External IDs	OMIM: 182160 MGI: 98384 HomoloGene: 36108 GeneCards: SPN
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,662,979 bp[1] End 29,670,876 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.35 cM Start 126,731,404 bp[2] End 126,736,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sperm pancreatic ductal cell bone marrow cells vena cava triceps brachii muscle internal globus pallidus ventral tegmental area external globus pallidus subthalamic nucleus Top expressed in blood thymus lymph node spleen body of femur submandibular gland subcutaneous adipose tissue paraventricular nucleus of hypothalamus lateral geniculate nucleus globus pallidus More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane signaling receptor activity Hsp70 protein binding heat shock protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane basement membrane cell surface uropod extracellular exosome external side of plasma membrane extracellular space Biological process negative regulation of cell adhesion positive regulation of protein phosphorylation negative regulation of type IV hypersensitivity response to protozoan T cell costimulation negative thymic T cell selection chemotaxis establishment or maintenance of cell polarity cellular defense response cell surface receptor signaling pathway negative regulation of T cell proliferation defense response to bacterium immune response positive regulation of T cell proliferation regulation of immune response apoptotic signaling pathway regulation of defense response to virus negative regulation of T cell activation leukocyte migration signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6693 20737 Ensembl ENSG00000197471 ENSMUSG00000051457 UniProt P16150 P15702 RefSeq (mRNA) NM_001030288 NM_003123 NM_001037810 NM_009259 RefSeq (protein) NP_001025459 NP_003114 NP_001032899 NP_033285 Location (UCSC) Chr 16: 29.66 – 29.67 Mb Chr 7: 126.73 – 126.74 Mb PubMed search [3] [4]
Wikidata
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Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.^[5][6][7]

Function

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.^[5]

Clinical significance

Defects in the CD43 molecule are associated with the development of Wiskott–Aldrich syndrome.^[8] It also appears in about 25% of intestinal MALTomas.^{[citation needed]} Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.^[9]

Interactions

CD43 has been shown to interact with EZR^[10] and Moesin.^[10][11]