CD7
Identifiers
AliasesCD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
External IDsOMIM: 186820 MGI: 88344 HomoloGene: 4471 GeneCards: CD7
Orthologs
SpeciesHumanMouse
Entrez

924

12516

Ensembl

ENSG00000173762

ENSMUSG00000025163

UniProt

P09564

P50283

RefSeq (mRNA)

NM_006137

NM_009854

RefSeq (protein)

NP_006128

NP_033984

Location (UCSC)Chr 17: 82.31 – 82.32 MbChr 11: 120.93 – 120.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[5]

Function

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[5]

See also

Interactions

CD7 has been shown to interact with PIK3R1.[6][7]

Clinical significance

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173762 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025163 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CD7 CD7 molecule".
  6. ^ Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
  7. ^ Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831. S2CID 26388891.
  8. ^ Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F (October 2012). "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research. 36 (10): 1229–36. doi:10.1016/j.leukres.2012.05.006. PMID 22682984.
  9. ^ Stevens SR, Baron ED, Masten S, Cooper KD (October 2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology. 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID 12374541. S2CID 40541131.

Further reading

External links


Proteins: clusters of differentiation (see also list of human clusters of differentiation)
Cluster of differentiation by lineage
Categories