CD82
Identifiers
AliasesCD82, 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
External IDsOMIM: 600623 MGI: 104651 HomoloGene: 20512 GeneCards: CD82
Orthologs
SpeciesHumanMouse
Entrez

3732

12521

Ensembl

ENSG00000085117

ENSMUSG00000027215

UniProt

P27701

P40237

RefSeq (mRNA)

NM_001024844
NM_002231

RefSeq (protein)

NP_001020015
NP_002222

Location (UCSC)Chr 11: 44.56 – 44.62 MbChr 2: 93.25 – 93.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene.[5]

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[5]

Interactions

CD82 (gene) has been shown to interact with CD19,[6][7] CD63[8] and CD234.[9]

CD82 plays a key role in the development of endometriosis.[10]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085117 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027215 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CD82 CD82 molecule".
  6. ^ Imai T, Kakizaki M, Nishimura M, Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology. 155 (3): 1229–39. doi:10.4049/jimmunol.155.3.1229. PMID 7636191. S2CID 32942467.
  7. ^ Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.
  8. ^ Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. doi:10.4049/jimmunol.161.7.3282. PMID 9759843.
  9. ^ Hur J, Choi JI, Lee H, Nham P, Kim TW, Chae CW, et al. (April 2016). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–21. doi:10.1016/j.stem.2016.01.013. PMID 26996598.
  10. ^ Timologou A, Zafrakas M, Grimbizis G, Miliaras D, Kotronis K, Stamatopoulos P, Tarlatzis B (February 2016). "Immunohistochemical expression pattern of metastasis suppressors". European Journal of Obstetrics & Gynecology and Reproductive Biology. 199: 110–115. doi:10.1016/j.ejogrb.2016.02.004. PMID 26918694.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Categories