CDKN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDKN3, CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
External IDsOMIM: 123832 MGI: 1919641 HomoloGene: 3805 GeneCards: CDKN3
Orthologs
SpeciesHumanMouse
Entrez

1033

72391

Ensembl

ENSG00000100526

ENSMUSG00000037628

UniProt

Q16667

Q810P3

RefSeq (mRNA)

NM_001130851
NM_005192
NM_001330173

NM_028222
NM_001360041

RefSeq (protein)

NP_001124323
NP_001317102
NP_005183

NP_082498
NP_001346970

Location (UCSC)Chr 14: 54.4 – 54.42 MbChr 14: 47 – 47.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.[5][6][7]

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.[7]

Interactions

CDKN3 has been shown to interact with Cyclin-dependent kinase 2,[8][9][10] Cdk1[5][9] and MS4A3.[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100526 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037628 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.
  6. ^ Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
  7. ^ a b "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".
  8. ^ Yeh CT, Lu Su-Chuan, Chao Chung-Hao, Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. 305 (2): 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075.
  9. ^ a b Hannon GJ, Casso D, Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1731–5. Bibcode:1994PNAS...91.1731H. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873.
  10. ^ Harper JW, Adami G R, Wei N, Keyomarsi K, Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751. S2CID 13614794.
  11. ^ Donato JL, Ko Jon, Kutok Jeffery L, Cheng Tao, Shirakawa Taro, Mao Xiao-Quan, Beach David, Scadden David T, Sayegh Mohamed H, Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

Further reading

External links


PDB gallery
Esterase: protein tyrosine phosphatases (EC 3.1.3.48)
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