CIZ1
Identifiers
AliasesCIZ1, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1
External IDsOMIM: 611420 MGI: 1920234 HomoloGene: 8112 GeneCards: CIZ1
Orthologs
SpeciesHumanMouse
Entrez

25792

68379

Ensembl

ENSG00000148337

ENSMUSG00000039205

UniProt

Q9ULV3

n/a

RefSeq (mRNA)

NM_001252534
NM_001252536
NM_001252537
NM_001252538
NM_028412

RefSeq (protein)

n/a

Location (UCSC)Chr 9: 128.16 – 128.2 MbChr 2: 32.24 – 32.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[5][6]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[6]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[7]

Ciz1 mutant mice

Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.[8] Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.[8]

Interactions

CIZ1 has been shown to interact with P21.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148337 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
  6. ^ a b "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
  7. ^ Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi:10.1073/pnas.1210107109. PMC 3494940. PMID 23074256.
  8. ^ a b Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805. PMID 29154038.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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