CKM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I0E
Identifiers
Aliases	CKM, CKMM, M-CK, creatine kinase, M-type, CPK-M
External IDs	OMIM: 123310 MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,306,413 bp[1] End 45,322,875 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.67 cM Start 19,138,701 bp[2] End 19,156,766 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic diaphragm triceps brachii muscle gastrocnemius muscle deltoid muscle right ventricle body of tongue tibialis anterior muscle vena cava vastus lateralis muscle greater omentum Top expressed in digastric muscle ankle sternocleidomastoid muscle vastus lateralis muscle skeletal muscle tissue extraocular muscle temporal muscle triceps brachii muscle tibialis anterior muscle thoracic diaphragm More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity creatine kinase activity transferase activity, transferring phosphorus-containing groups nucleotide binding catalytic activity protein binding ATP binding kinase activity Cellular component cytoplasm cytosol extracellular space Biological process creatine metabolic process phosphocreatine biosynthetic process phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1158 12715 Ensembl ENSG00000104879 ENSMUSG00000030399 UniProt P06732 P07310 RefSeq (mRNA) NM_001824 NM_007710 RefSeq (protein) NP_001815 NP_031736 Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.14 – 19.16 Mb PubMed search [3] [4]
Wikidata
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Creatine kinase, muscle also known as MCK is a creatine kinase that in humans is encoded by the MCK gene.^[5]

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.