CLCN3

Identifiers

CLCN3, CLC3, ClC-3, chloride voltage-gated channel 3, NEDSBA, NEDHYBA

External IDs

OMIM: 600580 MGI: 103555 HomoloGene: 20435 GeneCards: CLCN3

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q33	Start	169,612,633 bp^[1]
Band	4q33	End	169,723,673 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8 B3.1\|8 30.9 cM	Start	61,363,423 bp^[2]
Band	8 B3.1\|8 30.9 cM	End	61,436,334 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

Brodmann area 46

retinal pigment epithelium

postcentral gyrus

islet of Langerhans

parotid gland

right ventricle

superior vestibular nucleus

Region I of hippocampus proper

pons

Top expressed in

mammillary body

ventromedial nucleus

lateral geniculate nucleus

lateral hypothalamus

cingulate gyrus

paraventricular nucleus of hypothalamus

subiculum

dorsal tegmental nucleus

arcuate nucleus

medial geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding volume-sensitive chloride channel activity PDZ domain binding protein homodimerization activity ion channel activity protein binding protein heterodimerization activity antiporter activity ATP binding chloride channel activity voltage-gated chloride channel activity solute:proton antiporter activity chloride ion binding
Cellular component	integral component of membrane endosome late endosome Golgi apparatus early endosome membrane membrane late endosome membrane synaptic vesicle vesicle membrane Golgi membrane plasma membrane transport vesicle membrane secretory granule cell surface early endosome specific granule phagocytic vesicle external side of plasma membrane cytoplasmic vesicle integral component of plasma membrane
Biological process	negative regulation of cell volume endosomal lumen acidification ion transport regulation of anion transmembrane transport chloride transport regulation of pH chloride transmembrane transport regulation of anion transport transmembrane transport transport synaptic vesicle lumen acidification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1182


12725

Ensembl


ENSG00000109572


ENSMUSG00000004319

UniProt


P51790


P51791

RefSeq (mRNA)


NM_001243372 NM_001243374 NM_001829 NM_173872


NM_007711 NM_173873 NM_173874 NM_173876

RefSeq (protein)


NP_001230301 NP_001230303 NP_001820 NP_776297


NP_031737 NP_776298 NP_776299 NP_776301

Location (UCSC)

Chr 4: 169.61 – 169.72 Mb

Chr 8: 61.36 – 61.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

H⁺/Cl⁻ exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.^[5]

Interactions

CLCN3 has been shown to interact with PDZK1.^[6]

References

External links

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

Interactions

See also

References

Further reading

External links