Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[5] It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[6] [supplied by OMIM][5]
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[7]
Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.[7]