CLDN5
Identifiers
Aliases	CLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin 5, TMDVCF
External IDs	OMIM: 602101 MGI: 1276112 HomoloGene: 2459 GeneCards: CLDN5
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 19,523,024 bp[1] End 19,527,545 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 11.63 cM Start 18,595,597 bp[2] End 18,597,012 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of lung upper lobe of left lung pericardium lower lobe of lung subcutaneous adipose tissue inferior olivary nucleus olfactory bulb tibial nerve putamen Top expressed in right lung right lung lobe left lung external carotid artery renal corpuscle internal carotid artery left lung lobe medial ganglionic eminence iris carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component membrane apicolateral plasma membrane cortical actin cytoskeleton cell-cell junction integral component of membrane bicellular tight junction plasma membrane cell junction Biological process cell-cell junction assembly transforming growth factor beta receptor signaling pathway outflow tract morphogenesis learning positive regulation of establishment of endothelial barrier roof of mouth development calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules face morphogenesis regulation of bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7122 12741 Ensembl ENSG00000184113 ENSMUSG00000041378 UniProt O00501 O54942 RefSeq (mRNA) NM_003277 NM_001130861 NM_001363066 NM_001363067 NM_013805 RefSeq (protein) NP_001124333 NP_003268 NP_001349995 NP_001349996 NP_038833 Location (UCSC) Chr 22: 19.52 – 19.53 Mb Chr 16: 18.6 – 18.6 Mb PubMed search [3] [4]
Wikidata
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Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.^[5][6][7] It belongs to the group of claudins.

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.^[7]

Interactions

CLDN5 has been shown to interact with CLDN1^[8] and CLDN3.^[8]