CLIC1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N

Identifiers

Aliases

CLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1

External IDs

OMIM: 602872 MGI: 2148924 HomoloGene: 20343 GeneCards: CLIC1

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.33	Start	31,730,581 bp^[1]
Band	6p21.33	End	31,739,763 bp^[1]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• voltage-gated ion channel activity • GO:0001948 protein binding • chloride channel activity • cadherin binding • glutathione transferase activity
Cellular component	• cytoplasm • integral component of membrane • vesicle • nuclear membrane • blood microparticle • nuclear envelope • membrane • plasma membrane • chloride channel complex • mitochondrion • brush border • perinuclear region of cytoplasm • extracellular exosome • nucleus • extracellular space
Biological process	• regulation of ion transmembrane transport • ion transport • regulation of cell cycle • regulation of mitochondrial membrane potential • positive regulation of osteoblast differentiation • chloride transport • platelet aggregation • signal transduction • chloride transmembrane transport • glutathione metabolic process • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1192


114584

Ensembl

ENSG00000213719 ENSG00000223639 ENSG00000226248 ENSG00000226651 ENSG00000226417
ENSG00000230685 ENSG00000206394


ENSMUSG00000007041

UniProt


O00299


Q9Z1Q5

RefSeq (mRNA)


NM_001288 NM_001287593 NM_001287594


NM_033444

RefSeq (protein)


NP_001274522 NP_001274523 NP_001279


NP_254279

Location (UCSC)

Chr 6: 31.73 – 31.74 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.^[4]^[5]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.^[5]

Interactions

CLIC1 has been shown to interact with TRAPPC2.^[6]

References

External links

PDB gallery

PDB gallery
1k0m: Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms 1k0n: Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione 1k0o: Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel 1rk4: Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

Interactions

See also

References

Further reading

External links