CLIC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
External IDsOMIM: 602872 MGI: 2148924 HomoloGene: 20343 GeneCards: CLIC1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288
NM_001287593
NM_001287594

NM_033444

RefSeq (protein)

NP_001274522
NP_001274523
NP_001279

NP_254279

Location (UCSC)Chr 6: 31.73 – 31.74 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[4][5]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[5]

Interactions

CLIC1 has been shown to interact with TRAPPC2.[6]

See also

References

  1. ^ a b c ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 GRCh38: Ensembl release 89: ENSG00000213719, ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem. 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710.
  5. ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1".
  6. ^ Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. Netherlands. 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486. S2CID 8573651.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.