CLIC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N
Identifiers
Aliases	CLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
External IDs	OMIM: 602872 MGI: 2148924 HomoloGene: 20343 GeneCards: CLIC1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,730,581 bp[1] End 31,739,763 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.58 cM Start 35,268,942 bp[2] End 35,277,725 bp[2]
RNA expression pattern Bgee Top expressed in blood monocyte rectum gallbladder islet of Langerhans placenta right lung appendix upper lobe of left lung spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity GO:0001948 protein binding chloride channel activity cadherin binding glutathione transferase activity Cellular component cytoplasm integral component of membrane vesicle nuclear membrane blood microparticle nuclear envelope membrane plasma membrane chloride channel complex mitochondrion brush border perinuclear region of cytoplasm extracellular exosome nucleus extracellular space Biological process regulation of ion transmembrane transport ion transport regulation of cell cycle regulation of mitochondrial membrane potential positive regulation of osteoblast differentiation chloride transport platelet aggregation signal transduction chloride transmembrane transport glutathione metabolic process transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1192	114584
Ensembl	ENSG00000213719 ENSG00000223639 ENSG00000226248 ENSG00000226651 ENSG00000226417 ENSG00000230685 ENSG00000206394	ENSMUSG00000007041
UniProt	O00299	Q9Z1Q5
RefSeq (mRNA)	NM_001288 NM_001287593 NM_001287594	NM_033444
RefSeq (protein)	NP_001274522 NP_001274523 NP_001279	NP_254279
Location (UCSC)	Chr 6: 31.73 – 31.74 Mb	Chr 17: 35.27 – 35.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.^[5][6]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.^[6]

Interactions

CLIC1 has been shown to interact with TRAPPC2.^[7]