CLIC1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N |
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Identifiers |
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Aliases | CLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1 |
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External IDs | OMIM: 602872 MGI: 2148924 HomoloGene: 20343 GeneCards: CLIC1 |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 31.73 – 31.74 Mb | Chr 17: 35.27 – 35.28 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
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Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[5][6]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[6]
Interactions
CLIC1 has been shown to interact with TRAPPC2.[7]
PDB gallery
PDB gallery |
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1k0m: Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms
1k0n: Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione
1k0o: Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel
1rk4: Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1
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Membrane transport protein: ion channels (TC 1A)