CLIC6
Identifiers
AliasesCLIC6, CLIC1L, chloride intracellular channel 6
External IDsOMIM: 615321 MGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6
Orthologs
SpeciesHumanMouse
Entrez

54102

209195

Ensembl

ENSG00000159212

ENSMUSG00000022949

UniProt

Q96NY7

Q8BHB9

RefSeq (mRNA)

NM_053277
NM_001317009

NM_172469

RefSeq (protein)

NP_001303938
NP_444507

NP_766057

Location (UCSC)Chr 21: 34.67 – 34.72 MbChr 16: 92.28 – 92.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3.[7]

Function

CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159212 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022949 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  6. ^ a b "Entrez Gene: CLIC6 chloride intracellular channel 6".
  7. ^ Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
  8. ^ Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi:10.1016/j.jbc.2023.105349. PMC 10641671. PMID 37838179.

Further reading

  • Singh H (May 2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–2121. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
  • Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, et al. (August 2002). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mammalian Genome. 13 (8): 456–462. doi:10.1007/s00335-001-2157-0. PMID 12226712. S2CID 26059147.
  • Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
  • Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
  • Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, et al. (November 2003). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene. 320: 31–40. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)
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