CNKSR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDsOMIM: 603272 MGI: 2670958 HomoloGene: 4604 GeneCards: CNKSR1
Orthologs
SpeciesHumanMouse
Entrez

10256

194231

Ensembl

ENSG00000142675

ENSMUSG00000028841

UniProt

Q969H4

A2A9K7

RefSeq (mRNA)

NM_001297647
NM_001297648
NM_006314

NM_001081047

RefSeq (protein)

NP_001284576
NP_001284577
NP_006305

NP_001074516

Location (UCSC)Chr 1: 26.18 – 26.19 MbChr 4: 133.96 – 133.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[5][6]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[6]

Interactions

CNKSR1 has been shown to interact with RhoD[7] and RASSF1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142675 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028841 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi:10.1016/S0092-8674(00)81766-3. PMID 9814705. S2CID 16587330.
  6. ^ a b "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
  7. ^ Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
  8. ^ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.

Further reading

External links


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