ATF6B
Identifiers
Aliases	ATF6B, CREB-RP, CREBL1, G13, activating transcription factor 6 beta
External IDs	OMIM: 600984 MGI: 105121 HomoloGene: 31238 GeneCards: ATF6B
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,115,264 bp[1] End 32,128,253 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.22 cM Start 34,866,120 bp[2] End 34,874,048 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right uterine tube right lobe of thyroid gland spleen left lobe of thyroid gland gallbladder canal of the cervix pituitary gland lymph node appendix Top expressed in yolk sac lip neural tube thymus entorhinal cortex superior frontal gyrus ganglionic eminence external carotid artery ascending aorta cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding cAMP response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane intracellular anatomical structure integral component of endoplasmic reticulum membrane protein-DNA complex endoplasmic reticulum nucleus endomembrane system nucleolus RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of transcription by RNA polymerase II transcription, DNA-templated endoplasmic reticulum unfolded protein response ATF6-mediated unfolded protein response response to unfolded protein signal transduction transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of ATF6-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1388 12915 Ensembl ENSG00000213676 ENSG00000228628 ENSG00000234539 ENSG00000168468 ENSMUSG00000015461 UniProt Q99941 O35451 RefSeq (mRNA) NM_004381 NM_001136153 NM_017406 RefSeq (protein) NP_001129625 NP_004372 n/a Location (UCSC) Chr 6: 32.12 – 32.13 Mb Chr 17: 34.87 – 34.87 Mb PubMed search [3] [4]
Wikidata
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CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.^[5][6]

Function

The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.^[5]