CRTC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDsOMIM: 608972 MGI: 1921593 HomoloGene: 18765 GeneCards: CRTC2
Orthologs
SpeciesHumanMouse
Entrez

200186

74343

Ensembl

ENSG00000160741

ENSMUSG00000027936

UniProt

Q53ET0

Q3U182

RefSeq (mRNA)

NM_181715

NM_028881
NM_001357152

RefSeq (protein)

NP_859066

NP_083157
NP_001344081

Location (UCSC)Chr 1: 153.95 – 153.96 MbChr 3: 90.16 – 90.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[5][6][7]

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2[10] and YWHAQ.[10][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160741 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027936 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
  6. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  7. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  8. ^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585.
  9. ^ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7): eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.
  10. ^ a b Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
  11. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

External links

Transcription coregulators
Categories