PPBP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1TVX, 1F9P, 1NAP
Identifiers
Aliases	PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
External IDs	OMIM: 121010 HomoloGene: 136759 GeneCards: PPBP
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 73,986,439 bp[1] End 73,988,190 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spongy bone blood bone marrow cells periodontal fiber spleen right lung biceps brachii upper lobe of left lung lower lobe of lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity cytokine activity glucose transmembrane transporter activity CXCR chemokine receptor binding chemokine activity protein binding Cellular component platelet alpha granule lumen extracellular region extracellular space tertiary granule lumen platelet alpha granule Biological process response to lipopolysaccharide regulation of cell population proliferation chemotaxis positive regulation of cell division platelet degranulation defense response to bacterium inflammatory response immune response chemokine-mediated signaling pathway defense response positive regulation of neutrophil chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity neutrophil degranulation cell chemotaxis G protein-coupled receptor signaling pathway glucose transmembrane transport neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5473 n/a Ensembl ENSG00000163736 n/a UniProt P02775 n/a RefSeq (mRNA) NM_002704 n/a RefSeq (protein) NP_002695 n/a Location (UCSC) Chr 4: 73.99 – 73.99 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.^[3]

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).^[4]

It is a protein that is released in large amounts from platelets following their activation.^[5] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.^[6][7]