Cytochrome P450, family 12, also known as CYP12, is a cytochrome P450 family found in insect genome belongs to Mitochondrial clan CYPs, which is located in the inner membrane of mitochondria(IMM).[1][2] The first gene identified in this family is the CYP12A1 from the Musca domestica (house fly), which is involved in insecticide resistance.[3] CYP12A1 protein localization in mitochondria by immunohistochemistry and absolute dependence on mitochondrial electron donors adrenodoxin reductase and adrenodoxin.[3]

Rabbit gene CYP8B1 was named CYP12 at the beginning of its discovery, because it hydroxylated its sterol substrate on the 12 position.[4] However, CYP12 is a family of insect P450s found in mitochondria, so this gene was renamed to CYP8B1.[5]

References

  1. ^ Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution". Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 121 (1–3): 15–22. doi:10.1016/s0742-8413(98)10027-0. PMID 9972448.
  2. ^ Tijet, N; Helvig, C; Feyereisen, R (10 January 2001). "The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogeny". Gene. 262 (1–2): 189–98. doi:10.1016/s0378-1119(00)00533-3. PMID 11179683.
  3. ^ a b Guzov, VM; Unnithan, GC; Chernogolov, AA; Feyereisen, R (15 November 1998). "CYP12A1, a mitochondrial cytochrome P450 from the house fly". Archives of Biochemistry and Biophysics. 359 (2): 231–40. doi:10.1006/abbi.1998.0901. PMID 9808765.
  4. ^ Eggertsen, G; Olin, M; Andersson, U; Ishida, H; Kubota, S; Hellman, U; Okuda, KI; Björkhem, I (13 December 1996). "Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase". The Journal of Biological Chemistry. 271 (50): 32269–75. doi:10.1074/jbc.271.50.32269. PMID 8943286. S2CID 84628848.
  5. ^ Nelson, DR (2006). "Cytochrome P450 Nomenclature, 2004". Cytochrome P450 Protocols. Methods in Molecular Biology. Vol. 320. pp. 1–10. doi:10.1385/1-59259-998-2:1. ISBN 1-59259-998-2. PMID 16719369.


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