Identifiers
OrganismLocusta migratoria
SymbolCYP305M2
UniProtA0A410UD22
Other data
EC number1.14.-.-
Search for
StructuresSwiss-model
DomainsInterPro

CYP305M2 (formerly called LM16181) is a cytochrome P450 enzyme found in migratory locust (Locusta migratoria) that catalyzes the key step of biosynthesis of phenylacetonitrile (PAN).[1][2] PAN in turn is used as an aposematic chemical defense against predators.

Biosynthesis of phenylacetonitrile catalyzed by CYP305M2 and subsequent decomposition to benzaldehyde and cyanide

References

  1. ^ Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L (January 2019). "Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor". Science Advances. 5 (1): eaav5495. Bibcode:2019SciA....5.5495W. doi:10.1126/sciadv.aav5495. PMC 6357733. PMID 30746481.
  2. ^ "Cytochrome P450 [Locusta migratoria]". NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.


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