CYP3A43
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R
Identifiers
Aliases	CYP3A43, cytochrome P450 family 3 subfamily A member 43
External IDs	OMIM: 606534 HomoloGene: 136124 GeneCards: CYP3A43
EC number	1.14.14.56
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 99,828,013 bp[1] End 99,866,093 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver body of pancreas jejunal mucosa sperm skeletal muscle tissue prostate gastrocnemius muscle testicle pharynx n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 64816 n/a Ensembl ENSG00000021461 n/a UniProt Q9HB55 n/a RefSeq (mRNA) NM_001278921 NM_022820 NM_057095 NM_057096 n/a RefSeq (protein) NP_001265850 NP_073731 NP_476436 NP_476437 n/a Location (UCSC) Chr 7: 99.83 – 99.87 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.^[3][4][5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[5]