CYP4B1
Identifiers
Aliases	CYP4B1, CYPIVB1, P-450HP, cytochrome P450 family 4 subfamily B member 1
External IDs	OMIM: 124075 MGI: 103225 HomoloGene: 128045 GeneCards: CYP4B1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33 Start 46,757,838 bp[1] End 46,819,413 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D1|4 53.06 cM Start 115,481,922 bp[2] End 115,504,920 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right lung lower lobe of lung right uterine tube upper lobe of lung upper lobe of left lung tibial nerve urinary bladder palpebral conjunctiva trachea Top expressed in right lung lobe superior surface of tongue kidney olfactory epithelium left lung trachea interventricular septum jejunum brown adipose tissue duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding metal ion binding fluorene oxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity aromatase activity toxic substance binding monooxygenase activity Cellular component organelle membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process biphenyl metabolic process cellular aromatic compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1580 13120 Ensembl ENSG00000142973 ENSMUSG00000028713 UniProt P13584 Q64462 RefSeq (mRNA) NM_000779 NM_001099772 NM_001319161 NM_001319162 NM_001319163 NM_007823 RefSeq (protein) NP_000770 NP_001093242 NP_001306090 NP_001306091 NP_001306092 NP_031849 Location (UCSC) Chr 1: 46.76 – 46.82 Mb Chr 4: 115.48 – 115.5 Mb PubMed search [3] [4]
Wikidata
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Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.^[5]

Mouse Mutant Alleles for Cyp4b1

Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI	Cyp4b1
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse.	CYP4B1tm1a(KOMP)Wtsi
Example structure of targeted conditional mutant allele for this gene
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1: see Knockout mouse