The evolutionary divergence of the CYP superfamily collected in 1990, CYP55 is in the branch of prokaryotic CYPs

Cytochrome P450, family 55, also known as CYP55, is a cytochrome P450 family in fungi supposed to derived from horizontal gene transfer of Actinomycetes CYP105 family member in the ancestor of all Dikarya (Ascomycota and Basidiomycota).[1][2] The first gene identified in this family is the CYP55A1 from Fusarium oxysporum encoding the NADPH dependent reductase of nitrous oxide (P450nor cytochrome P450nor).[3][4]

References

  1. ^ Chen W, Lee MK, Jefcoate C, Kim SC, Chen F, Yu JH (June 2014). "Fungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary origin". Genome Biology and Evolution. 6 (7): 1620–34. doi:10.1093/gbe/evu132. PMC 4122930. PMID 24966179.
  2. ^ Nelson DR (January 2018). "Cytochrome P450 diversity in the tree of life". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1866 (1): 141–154. doi:10.1016/j.bbapap.2017.05.003. PMC 5681887. PMID 28502748.
  3. ^ Shoun H, Tanimoto T (June 1991). "Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction". The Journal of Biological Chemistry. 266 (17): 11078–82. doi:10.1016/S0021-9258(18)99130-1. PMID 2040619.
  4. ^ Zhang L, Kudo T, Takaya N, Shoun H (September 2002). "The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH". The Journal of Biological Chemistry. 277 (37): 33842–7. doi:10.1074/jbc.M203923200. PMID 12105197. S2CID 37899494.


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