Cytochrome P450, family 9, also known as CYP9, is a cytochrome P450 family found in Insect genome,[1][2] CYP9 and insect CYP6 family belong to the same clan as mammalian CYP3 and CYP5 families.[3] The first gene identified in this family is the CYP9A1 from the Heliothis virescens (tobacco budworm), which is involved in thiodicarb insecticide resistance.[4] Subfamily CYP9A in Lepidopteran play important roles in insecticide resistance, can metabolize esfenvalerate efficiently.[5]

References

  1. ^ Stevens, JL; Snyder, MJ; Koener, JF; Feyereisen, R (July 2000). "Inducible P450s of the CYP9 family from larval Manduca sexta midgut". Insect Biochemistry and Molecular Biology. 30 (7): 559–68. doi:10.1016/s0965-1748(00)00024-2. PMID 10844248.
  2. ^ Ishak, IH; Kamgang, B; Ibrahim, SS; Riveron, JM; Irving, H; Wondji, CS (January 2017). "Pyrethroid Resistance in Malaysian Populations of Dengue Vector Aedes aegypti Is Mediated by CYP9 Family of Cytochrome P450 Genes". PLOS Neglected Tropical Diseases. 11 (1): e0005302. doi:10.1371/journal.pntd.0005302. PMC 5289618. PMID 28114328.
  3. ^ Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution". Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 121 (1–3): 15–22. doi:10.1016/s0742-8413(98)10027-0. PMID 9972448.
  4. ^ Rose, RL; Goh, D; Thompson, DM; Verma, KD; Heckel, DG; Gahan, LJ; Roe, RM; Hodgson, E (June 1997). "Cytochrome P450 (CYP)9A1 in Heliothis virescens: the first member of a new CYP family". Insect Biochemistry and Molecular Biology. 27 (6): 605–15. doi:10.1016/s0965-1748(97)00036-2. PMID 9304798.
  5. ^ Shi, Y; Jiang, Q; Yang, Y; Feyereisen, R; Wu, Y (August 2021). "Pyrethroid metabolism by eleven Helicoverpa armigera P450s from the CYP6B and CYP9A subfamilies". Insect Biochemistry and Molecular Biology. 135: 103597. doi:10.1016/j.ibmb.2021.103597. PMID 34089822. S2CID 235353940.


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