Calabrese is an Italian surname, meaning literally "Calabrian" or "from Calabria". Notable people with the surname:

• Anthony O. Calabrese (1907–1991), Democratic Party politician in Ohio
• Anthony O. Calabrese Jr., son of the above and a judge and Republican Party politician in Ohio
• Edward Calabrese, American toxicologist
• Elizabeth Calabrese, New Jersey Democratic Party politician
• Frank Calabrese Sr. (1937–2012), Chicago mobster
• Gerald Calabrese (1925–2015), former college and professional basketball player and Democratic politician in New Jersey
• Giovanni Calabrese (born 1966), Italian rower and winner of a bronze medal in the 2000 Olympics
• Greg Calabrese, American soap opera actor
• John Calabrese, member of the Canadian band Danko Jones
• Karyn Calabrese (born 1947), American raw foodist and restaurateur
• Mike Calabrese, member of the band Lake Street Dive
• Salvatore Calabrese (1903–1973), Italian physician