KCNIP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDsOMIM: 604662 MGI: 1929258 HomoloGene: 8382 GeneCards: KCNIP3
Orthologs
SpeciesHumanMouse
Entrez

30818

56461

Ensembl

n/a

ENSMUSG00000079056

UniProt

Q9Y2W7

Q9QXT8
P0C092

RefSeq (mRNA)

NM_001034914
NM_013434

NM_001111331
NM_001291005
NM_019789

RefSeq (protein)

NP_001030086
NP_038462

NP_001104801
NP_001277934
NP_062763

Location (UCSC)n/aChr 2: 127.3 – 127.36 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[4][5][6]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[7][8] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.[9] Alternatively spliced transcript variants encoding different isoforms have been described.[6]

Interactions

Calsenilin has been shown to interact with PSEN1[4][10] and PSEN2.[4][11]

See also

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079056 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b c Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.
  5. ^ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.
  6. ^ a b "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".
  7. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
  8. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.
  9. ^ Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. doi:10.1038/ni.2823. PMC 4005385. PMID 24487321.
  10. ^ Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253. S2CID 24838995.
  11. ^ Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Membrane transport protein: ion channels (TC 1A)
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