CA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z93, 1Z97, 2HFW, 3UYN, 3UYQ
Identifiers
Aliases	CA3, CAIII, Car3, carbonic anhydrase 3
External IDs	OMIM: 114750 MGI: 88270 HomoloGene: 31298 GeneCards: CA3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.2 Start 85,373,436 bp[1] End 85,449,040 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A1|3 3.22 cM Start 14,928,572 bp[2] End 14,937,583 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle biceps brachii thoracic diaphragm gastrocnemius muscle triceps brachii muscle body of tongue deltoid muscle tibialis anterior muscle right lung gastric mucosa Top expressed in intercostal muscle subcutaneous adipose tissue white adipose tissue ankle body of femur brown adipose tissue sternocleidomastoid muscle vastus lateralis muscle triceps brachii muscle left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbonate dehydratase activity phosphatase activity zinc ion binding nickel cation binding metal ion binding lyase activity carbonic anhydrase Cellular component cytoplasm cytosol Biological process bicarbonate transport response to ethanol response to oxidative stress dephosphorylation response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 761 12350 Ensembl ENSG00000164879 ENSMUSG00000027559 UniProt P07451 P16015 RefSeq (mRNA) NM_005181 NM_007606 RefSeq (protein) NP_005172 NP_031632 Location (UCSC) Chr 8: 85.37 – 85.45 Mb Chr 3: 14.93 – 14.94 Mb PubMed search [3] [4]
Wikidata
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Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.^[5]

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient in muscles of Myasthenia Gravis patients.^[6] A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 have been found to be significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.^[7] The gene spans 10.3 kb and contains seven exons and six introns.^[8]