CA6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FE4
Identifiers
Aliases	CA6, CA-VI, GUSTIN, carbonic anhydrase 6
External IDs	OMIM: 114780 MGI: 1333786 HomoloGene: 20324 GeneCards: CA6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 8,945,867 bp[1] End 8,975,092 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 150,271,472 bp[2] End 150,285,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland skin of abdomen vulva hair follicle tongue superior surface of tongue thymus nipple blood body of tongue Top expressed in submandibular gland parotid gland lacrimal gland lip temporal muscle respiratory epithelium olfactory epithelium masseter muscle iris sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbonate dehydratase activity zinc ion binding metal ion binding lyase activity protein binding carbonic anhydrase Cellular component cytoplasm extracellular region cytosol extracellular exosome extracellular space Biological process bicarbonate transport detection of chemical stimulus involved in sensory perception of bitter taste one-carbon metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 765 12353 Ensembl ENSG00000131686 ENSMUSG00000028972 UniProt P23280 Q8N4G4 P18761 RefSeq (mRNA) NM_001215 NM_001270500 NM_001270501 NM_001270502 NM_009802 RefSeq (protein) NP_001206 NP_001257429 NP_001257430 NP_001257431 NP_033932 Location (UCSC) Chr 1: 8.95 – 8.98 Mb Chr 4: 150.27 – 150.29 Mb PubMed search [3] [4]
Wikidata
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Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene.^[5][6] It is also called 'gustin' because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia.^[7][8]

Function

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide, though its function in saliva is unknown.^[6]

It has been suggested that CA VI participates in the maintenance of appropriate pH homeostasis on tooth surfaces as well as in the mucosa of the gastrointestinal canal.