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This category groups enzymes that use nicotinamide adenine dinucleotide (NADP⁺ and its reduced form, NADPH) in redox reactions. See also Category:NADH-dependent enzymes.

In general, the NADP is not stably associated with the enzyme, being a coenzyme; hence, we call such enzymes "NADPH-dependent" enzymes, rather than simply "NADPH enzymes". By contrast, more stably bound ligands such as heme or iron-sulfur clusters are cofactors; thus, one speaks of "heme enzymes" or "iron-sulfur proteins".