This category comprises those ambassadors of the United States who have been awarded the rank of Career Ambassador by appointment of the President. As of 2018, there were only 62 ambassadors who had attained this rank since its inception in 1955. This is not a general category for ambassadors who have had a career within the Department of State as ambassadors.

The primary external reference for this list is the U.S. Department of State list of Career Ambassadors. Caveat: The State Department list appears to be current only up until 2018.