Charles Francis Adams may refer to:

• Charles Francis Adams Sr. (1807–1886), grandson of John Adams, son of John Quincy Adams, U.S. congressman, ambassador
• Charles Francis Adams Jr. (1835–1915), son of above, American Civil War general and president of the Union Pacific Railroad
• Charles Francis Adams III (1866–1954), nephew of above, U.S. Navy secretary
• Charles Francis Adams IV (1910–1999), son of above, president of Raytheon
• Charles Adams (ice hockey) (1876–1947), grocery magnate and founder of the Boston Bruins