Charles Lowe may refer to:

• Charles Lowe (cricketer) (1890–1953), English cricketer
• Charles Herbert Lowe (1920–2002), American herpetologist
• Charlie Lowe, American baseball player
• Chad Lowe (Charles Lowe, born 1968), American actor and director
• Charles Upton Lowe, physician, discoverer of oculocerebrorenal syndrome
• Charles Lowe (judge), judge of the Supreme Court of Victoria